Our special assays
Anti-Drug Antibody (ADA) assay development
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ADA tests play a pivotal role in drug development. These tests detect antibodies created in response to therapeutic biological drugs. The detection and characterization of anti-drug antibodies (ADA) are essential due to their possible profound effect on drug efficacy, safety, and patient well-being
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Who is required to perform ADA testing?
Regulatory agencies, including the FDA and EMA, mandate ADA testing for any company that develops biological products, such as protein / peptide-based drugs, therapeutic antibodies, vaccines, and gene therapies, etc. -
We develop ADA assays using an instrument that is the golden standard for this assay due to its high sensitivity and specificity
Multiplex Assays
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Quantitative multiplex proteomic analysis on a small volume of samples, including bodily fluids.
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Semi-quantitative analysis of single-cell proteomics.
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No need for separate bioinformatic analysis thanks to IsoSpeak®, an analytic program that can translate raw data into cell profiles and population shifts.
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Several available panels with over 15 analytes.
Mitochondrial Assays
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Isolation of mitochondria from cell culture.
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Replacement of indigenous mitochondria with donor mitochondria.
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ROS quantification, TMRM, heteroplasmy tests and more.
Multiple Tissue Arrays
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High throughput – up to hundreds of samples on the same slide.
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Flexible design.
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IHC scoring based on staining intensity and cell proportion.
Assay development
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Establishment of optimal conditions for IHC and ISH.
Antibodies
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Antibody profiling using IHC.
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Novel screening methods for production of monoclonal antibodies.
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ELISA of all types.
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ADA - Anti Drug Antibodies.
MS\MS​
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GLP compliant method development and validation.
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Detection and quantification of small molecules, peptides, RNA and DNA, proteins and antibodies in complex biological matrixes – plasma, serum, tissue, urine, saliva, CSF and more.
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Toxicity, Pharmacokinetics and Pharmacodynamics.
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Drug formulation and stability.
3D tumor cells - Spheroids​
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A method for replicating the tumor spatial organization, with an outer layer of highly proliferating cells, middle region comprising senescent cells and a core containing necrotic dead cells.
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Co-culturing of several types of cells from the tumor microenvironment for enhanced complexity.
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Penetration research into tumor cells by mirroring natural gradient of nutrients and environmental conditions.
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Complex gene expression which more closely resembles that of a tumor tissue in vivo.