Antibodies Profiling

Antibodies Profiling

Smart-Assays offers a wide verity of profiling options to meet the need for antibody profiling and characterization. We establish the IHC protocol, perform the analysis and evaluate and score the results.

 

Multi-Tissue Arrays:

Multi tissue microarrays (TMAs) consist of paraffin blocks in which up to 1000 separate tissue cores are assembled in array fashion to allow multiplex histological analysis. TMA can significantly accelerate the processing of a very large number of tissue specimens with excellent quality, good reliability and preservation of original tissue, with ultimate clinical benefit. We offer implementation of various commercially available TMAs to address specific aims:

  • Normal tissues array

  • Cancer samples vs. normal counterpart

  • Cancer vs. benign tumors

  • Cancer primaries vs. metastases

  • Cancer vs. benign lesions

  • Cancer samples of different morphological subtypes

  • Cancer samples of different clinical stages/grades

 

 

Examples

Normal tissues evaluation:

  • Performing human tissue evaluation for safety profile of   monoclonal antibodies.

  • Evaluation of human versus animal tissue in rodents or primates, for selection of optimal species profile when planning your toxicology studies.

Cancer tissues evaluation :

IHC evaluation of cancer tissues for clinical trial planning, tumors/patients stratification, target cohort and market evaluation. Development of drugs targeted to interrupt specific pathways present the opportunity to conduct clinical trials that use these molecular features to select patients, assign treatment or assess treatment outcomes. Preliminary tissue profiling, potentially allows the design of clinical trials with larger effect sizes and smaller sample sizes that can be completed faster.

Tissue Array Reporting Example:

Tissue MicroArray (TMA)

Typical reporting of MTA results, presenting  ‘Clinical data’ as reported by the customer and supporting immunohistochemical analysis, ‘IHC data’,  performed by Smart Assays

Intensity Assessment and Scoring:

 

IHC (Q) score – based on intensity (I) and proportion (P) of % cell staining:

Score = I0xP0 + I1xP1 + I2xP2 + I3xP3

Scoring Examples:

Contact

smart@assays.co.il

 

Tel: +972 (0)77-300-1087

Mobil: +972 (0)54-7241-251

Location

3 Pinchas Sapir St.,

Weizmann Science Park

Ness Ziona,

7414003 ISRAEL

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